Social distancing interventions can be effective against epidemics but are potentially detrimental for the economy. Businesses that rely heavily on face-to-face communication or close physical proximity when producing a product or providing a service are particularly vulnerable. The main cost of social distancing is insufficient division of labor.To a greater or lesser extent, all sectors will be affected by social distancing. Some sectors are hit by the intervention due to restricted face-to-face communication, others are hit due to restricting physical proximity of people. Some sectors are less affected across all dimensions. Examples include “Fishing, hunting and trapping,” “Printing and related support activities,” and manufacturing in general.