The COVID-19 pandemic has altered the business world in unprecedented and historic ways, the effects of which have been felt the world over. In the short-term, organizations have generally engaged in empathic pro-employee responses, and many have radically altered how and where employees work. The COVID-19 pandemic has the potential to result in multiple paradigm shifts in organizations that society, in general, has yet to fully anticipate. The spectrum of shifts range from personal to professional, individual to organizational, and across most industries. The world is at its most interdependent economically and has never faced this level of comprehensive interruption. Whereas the short-term effects have been felt and recognized by many, resulting paradigm shifts caused by the pandemic will likely have long-term effects of unknown scope and impact.